Muramasa: The Demon Blade Wiki

Orochimaru is the former monk Mumyo after using the Soul Transfer technique to take over Arashimaru's body.

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Mumyo resumes his mission to throw Japan into chaos, with his latest target being Chikushi Castle in Omi Province. All of the guards, nobility, and servants are slain. However, Shirohebi (in her final moments of lucidity) manages to hide the infant Hiroyuki Shuuma and give the baby to Shiranui for safekeeping. Orochimaru is aware of this development, but states that it's no use.

Later, he's seen battling an adult Shuuma (under the alias Jiraiya) and Tsunadehime.